Paediatric UK demyelinating disease longitudinal study (PUDDLS)

Paediatric UK demyelinating disease longitudinal study (PUDDLS)

BACKGROUND There is evidence that at least 5% of Multiple sclerosis (MS) cases manifest in childhood. Children with MS present with a demyelinating episode involving single or multiple symptoms prior to developing a second event (usually within two years) to then meet criteria for diagnosis. There is evidence from adult cohorts that the incidence and sex ratios of MS are changing and that child...

Epidemiology of paediatric renal stone disease in the UK.

BACKGROUND The previous epidemiological study of paediatric nephrolithiasis in Britain was conducted more than 30 years ago. AIMS To examine the presenting features, predisposing factors, and treatment strategies used in paediatric stones presenting to a British centre over the past five years. METHODS A total of 121 children presented with a urinary tract renal stone, to one adult and one ...

The Obstructive Lung Disease in Northern Sweden (OLIN) longitudinal paediatric study I--the first 10 years.

BACKGROUND Prospective studies of asthma and allergic conditions based on the general population are scarce. AIM To summarize the methods and main results from a prospective study among school children. METHODS In 1996, a cohort of 3525 children aged 7/8 years in Northern Sweden were invited to a questionnaire survey using an expanded ISAAC protocol, and 97% participated. The cohort has bee...

Fitness, Physical Activity, And Cardiovascular Disease: Longitudinal And Genetic Analyses In The UK Biobank Study

Acute fulminant demyelinating disease: a descriptive study of 60 patients.

BACKGROUND Acute demyelinating encephalomyelitis (ADEM) is characterized by a severe inflammatory attack, frequently secondary to infectious events or vaccinations. To date, no clear criteria exist for ADEM, and the risk of subsequent evolution to multiple sclerosis (MS) remains unknown. OBJECTIVE To evaluate the risk of evolution to MS after a first episode of ADEM. DESIGN Observational, r...